Changes in version 0.2.3 (2025-10-08) - Added three new vignettes on phase I/II designs, TITE-designs, and combination designs. - Added BOIN-COMB MTD selector - Added tests and docs - Fixed bugs and typos Changes in version 0.2.2 - Added boin12_rds() to tabulate desirability scores in a BOIN12 trial. Changes in version 0.2.1 - Added unadmit_untested(), a selector to explicitly mark any untested and non-recomended dose as inadmissible via dose_admissible(). Changes in version 0.2.0 - Added support for treatment combinations by allowing dose to become a vector of indices rather than a scalar. - Added BOIN COMB design for treatment combinations. Changes in version 0.1.10 (2024-06-27) - Added TITE methods Changes in version 0.1.9 (2024-05-22) - Fixed inheritance problems with as_tibble, summary and print dose_selector generics - Added many tests of dose_selector consistency. Changes in version 0.1.8 (2024-02-23) - Made tests faster for CRAN Changes in version 0.1.7 - Added ability to import and export PatientSamples - Split the simulation vignette Changes in version 0.1.6 - Implement efficient simulation comparison method of Sweeting et al. in simulate_compare() - Implement BOIN12 design - Add MTD / OBD selectors for TPI, mTPI, mTPI2 and BOIN12 for final dose choice at end of a trial Changes in version 0.1.5 (2023-05-29) - Add mTPI2 dose-finding method - Fixed some bugs Changes in version 0.1.4 (2020-10-18) - Added Neuenschwander, Branson & Sponer's method for phase I. - Added Ji et al.'s TPI & mTI methods for phase I. - Added Thall & Cook's EffTox method for phase I/II. - Added Wages & Tait's method for phase I/II. Changes in version 0.1.3 (2020-05-12) - Mainly small changes to comply with dplyr v1.0. - simulations and crystallised_dose_paths given summary method - NOTE squash Changes in version 0.1.2 (2020-04-14) - Methods for simulation and calculating dose-paths added. - A bit more on the general selector interface. - Everything new has tests, and more tests on old stuff. Changes in version 0.1.1 (2020-03-08) - Initial release. - dfcrm, BOIN, 3+3 models supported. - several objects included to facilitate stopping at different events. - class for a fixed escalation plan included, as sometimes used with CRM.