NEWS

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trialr 0.1.5 (2020-10-15)

Added the Neuenschwander, Branson & Gsponer model for dose-escalation. Also added a method for calculating EffTox parameter priors. Re-ordered vignettes to be more intuitive. Suppressed all the MCMC log messages in the tests scripts.

trialr 0.1.4 (2020-04-06)

Updated dependencies to account for recent breaking changes in tibble v3.0.0.

trialr 0.1.3 (2020-01-08)

Adjusted uses of tidyr::unnest to suppress warnings when using v1.0 of tidyr.

trialr 0.1.2 (2019-06-25)

Added the AugBin model for phase II response assessment in cancer. Just the two-stage single-arm version added for now. The others will follow. Also added a general routine for running simulation studies.

trialr 0.1.1 (2019-05-24)

Plumbed in support for tidybayes. Added pathways analysis for CRM and rewrote the same for EffTox.

trialr 0.1.0 (2019-04-21)

Added TITE-CRM implmentation plus tests and vignette. Rebased package to the format now advocated by rstantools.

trialr 0.0.7 (2019-03-03)

Making package work with staged installation, with help from Tomas Kalibera.

trialr 0.0.6 (2019-01-17)

Fixing some duplicated vignette titles

trialr 0.0.5 (2018-11-12)

Adding changes advised by rstan maintainer so that package may build on Solaris.

trialr 0.0.4 (2018-10-24)

Updated to use rstan 2.18.1, which in-turn has been updated to use C++14.

trialr 0.0.3 (2018-08-09)

This release updates some Stan code that was generating C++ code that would compile on Linux, Mac & Windows, but not Solaris.

trialr 0.0.2 (2018-08-08)

This release adds the Continual Reassessment Method (CRM) for dose-finding. Four model variants are currently given:

• empiric likelihood with normal prior on slope;
• logistic likelihood with constant intercept and normal prior on slope;
• logistic likelihood with constant intercept and gamma prior on slope;
• logistic likelihood with normal priors on the intercept and slope.

This release also adds general model-fitting functions stan_crm and stan_efftox. It also adds S3 classes crm_fit and efftox_fit with the expected generic methods.

Unit tests have been added.

trialr 0.0.1 (2017-11-21)

First release with implementations of:

• Thall & Cook's EffTox dose-finding clinical trial design;
• Thall et al.'s hierarchical Bayesian phase II design for diseases with multiple subtypes
• Brock et al.'s BEBOP design for efficacy and toxicity outcomes in phase II where predictive information