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EffTox, Wages & Tait, and BOIN12 - Efficacy & Toxicity Designs1 years ago
Introduction | Outcome nomenclature | EffTox | Wages & Tait | BOIN12 | Implementation in escalation | Final dose selection | RDS tabulation | Dose paths | Simulation | References
BOIN - Bayesian Optimal Interval Design1 years ago
Introduction | Summary of the BOIN Design | Implementation in escalation | Final dose selection | Dose paths | Simulation | References
BOIN-COMB - Treatment Combination Designs1 years ago
Introduction | Outcome nomenclature | BOIN-COMB | Implementation in escalation | Final dose selection | Combination with other dose selectors | Dose paths | Simulation | References
CRM - Continual Reassessment Method1 years ago
Introduction | Summary of the CRM Design | Hyperbolic tangent model | Empiric model (aka power model) | One-parameter logistic model | Two-parameter logistic model | Priors | Toxicity skeletons and standardised doses | Implementation in escalation | dfcrm | trialr | dfcrm vs trialr | Dose paths | Simulation | References
mTPI - Modified Toxicity Probability Interval Design1 years ago
Introduction | Summary of the mTPI Design | Implementation in escalation | Final dose selection | Dose paths | Simulation | References
NBG - Neuenschwander, Branson & Gsponer1 years ago
Summary of the design | Implementation in escalation | Future work | Dose paths | Simulation | References
TITE-CRM and TITE-NBG - Time-to-Event Designs1 years ago
Introduction | TITE-CRM | TITE-NBG | Implementation in escalation | Dose paths | Simulation | References
TPI - Toxicity Probability Interval Design1 years ago
Introduction | Summary of the TPI Design | Implementation in escalation | Final dose selection | Dose paths | Simulation | References
Using escalation1 years ago
Introduction | Supported Interface
Comparing dose-escalation designs by simulation2 years ago
Introduction | Comparing competing designs | Working with PatientSamples | Exporting the underlying latent variables | Calculating potential outcomes | Importing the underlying latent variables | Correlated toxicity and efficacy outcomes | Further refinements | References
Simulating dose-escalation trials2 years ago
Introduction | Simulating trials in escalation | The simplest example | A more complex example | Further refinements | Cohort size | Sampling the conclusion of partly-observed trials | Next dose | All model fits | Big trials | References
Working with dose-paths6 years ago
Introduction | Other Models | CRM | BOIN | Further options | Non-uniform cohorts | Partially completed trials | Next dose | Crystallised dose-paths | Dose-paths vs simulation | References